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Drugs Containing Metformin

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Metformin is an FDA-approved drug used to treat diabetes. It is often combined with other drugs and marketed as diabetes medication. Like many drugs, metformin causes side effects that can be severe. Some of these side effects could even be fatal. Many patients have been prescribed drugs which contain metformin, so the potential exposure to its side effects is broad. If you’re using a diabetes medication with metformin, and you’ve suffered injury, you could be entitled to compensation. Our firm is aggressively investigating these cases and pursuing litigation for victims.

How does metformin work?

Metformin works by decreasing glucose production in the liver while improving your body’s response to insulin. The medicine ultimately lowers blood sugar levels and restores how your body uses food to make energy. It is often prescribed along with a diet, exercise, and lifestyle regimen, including weight loss. Metformin may or may not cause weight loss, but it does not cause weight gain.

What are the side effects associated with metformin?

The drug is known to cause numerous side effects, which include:

  • Low blood sugar (hypoglycemia) and low blood levels of vitamin B-12
  • Gastrointestinal problems such as diarrhea, flatulence, and abdominal pain
  • Heartburn
  • Nausea
  • Vomiting, chills, and dizziness
  • Physical weakness, also known as asthenia
  • Muscle pain, or myalgia
  • Upper respiratory tract infection and chest pain

Are there any fatal side effects linked with metformin?

One potentially fatal side effect linked to metformin is lactic acidosis. This occurs when the body has high levels of lactate and, consequently, low pH in the blood. Lactic acidosis can cause other severe complications including shock, coma, organ failure, and death. Symptoms of lactic acidosis that metformin users should be on the lookout for include:

  • Disorientation
  • Muscle Pain
  • Weakness
  • Fatigue
  • Abdominal Pain And Discomfort
  • Jaundice
  • Reduced Appetite
  • Nausea
  • Headaches

What is Fournier’s gangrene?

The FDA has issued a warning concerning a rare but potentially fatal bacterial genital infection linked to some diabetes medications.  Fournier’s gangrene is connected to a class of type 2 diabetes medicines called sodium-glucose cotransporter-2 (SGLT2) inhibitors.  Symptoms include tenderness, redness, or swelling of the genitals or the area from the genitals back to the rectum.  Patients with a fever above 100.4 F or a general unwell feeling may also be suffering from Fournier’s gangrene.  If you experience these symptoms, seek medical attention immediately.  You may also be entitled to compensation for medical costs and other damages.

Which diabetes medications contain metformin?

Numerous diabetes medications contain metformin along with other substances. Side effects may be caused by metformin or by other drugs. Patients should be familiar with these medications and document common complications they experience.


Janumet is an oral type-2 diabetes medication containing sitagliptin and metformin. It was approved by the FDA in 2007 and is manufactured by Merck & Co. Janumet has been connected to an increased risk of pancreatic cancer, inflamed pancreas (pancreatitis), and thyroid cancer. It may also be linked to rhabdomyolysis, a breakdown of muscle tissue that releases a harmful protein into the bloodstream.

Kombiglyze XR

Kombiglyze XR is also an oral type-2 diabetes medication, originally manufactured by Bristol-Myers Squibb (later purchased by AstraZeneca). A DPP-4 inhibitor, it contains saxagliptin and metformin and was approved by the FDA in 2010. Similar to Janumet, it has been linked to pancreatitis, pancreatic cancer, thyroid cancer, and potentially to rhabdomyolysis. It may also be connected to heart failure.


Invokamet is another oral type-2 diabetes medication that was approved by the FDA in 2014. It contains canagliflozin and metformin and is an SGLT2 inhibitor. Invokamet is manufactured by Janssen Pharmaceuticals. This medication could increase the risk of diabetic ketoacidosis. Other complications include urinary tract infections, bone fractures, leg and foot amputations, and acute injury to the kidneys.


Kazano treats type-2 diabetes. It is an oral medication, approved by the FDA in 2013, and contains alogliptin and metformin. It is another DPP-4 inhibitor and is manufactured by Takada Pharmaceuticals. Side effects include an increased risk of pancreatitis, pancreatic cancer, and thyroid cancer. It may also be linked to rhabdomyolysis and heart failure.

What should I do if I experience any side effects?

The first thing you should do is see a physician or health care professional and make sure you are treated. Next, document as much as you can about your side effects. This includes medical or hospital records along with any prescription medications you are given to treat these conditions. Also make sure you keep records related to your diabetes medication, including your prescribed dosage. If you took any other medications before or while experiencing side effects, document those as well.

How can a lawyer help me?

A Georgia product liability attorney can help hold any responsible parties liable for your injuries. Lawsuits have been filed against diabetes medications that allege drug manufacturers produced a defective and dangerous drug without proper warning. If you have been injured, you could be entitled to compensation for medical bills, lost wages, and more.

Contact the dedicated legal team at Schneider Hammers today. Our firm will review and investigate your claims and determine whether you may have a case.